In recent decades, major strides have been made in the emerging field of regenerative medicine. Various treatments, including stem cell and PRP (platelet-rich plasma) therapy have been developed and refined, and doctors have enabled millions of patients to recover from injuries and relieve their chronic pain symptoms without having to resort to invasive measures. Add to the list of breakthrough regenerative medical practices, the therapeutic use of exosomes.
What, you may ask, is an exosome? Exosomes are extracellular lipid vesicles (a small structure within a cell) that, when released by stem cells in response to an injury, transport proteins and genetic information between both neighboring and distant cells.
Scientists have been aware of exosomes for several decades, but only in recent years have they realized the importance of these tiny bubbles that are constantly racing through the human bloodstream – namely the fact that some cells use exosomes to transfer messenger RNAs (ribonucleic acid), polymeric molecules essential in various biological roles in coding, decoding, regulation and expression of genes. That discovery has led to the use of exosomes as an emergent new regenerative modality and, in conjunction with stem cell therapy, has enhanced its regenerative benefits.
Mesenchymal stem cell exosomes are derived from human tissue and purified using proprietary processing. What makes them special is that they contain a wide variety of growth factors that stimulate and modulate many of the processes involving in healing damaged tissue.
Exosomes help to send signals to other regenerative factors like stem cells and cytokines, and chemokines to help these regenerative tissues find and repair what they need to repair. They deliver more than 200 signaling proteins including: anti-inflammatory cytokines, angiogenic growth factors, anti-tumor signals, and regenerative and healing signals that inhibit cell death.
Exosomes even have “off” and “on” switches. The micro RNA off switches turn off chronic inflammatory cytokines and matrix catabolic enzymes, while the Messenger RNA on switches turn on regenerative mechanisms such as the aforementioned anti-inflammatory cytokines and angiogenic growth factors, as well as many other signals.
As such, injectable exosomes are used by health care providers to treat a wide range of injuries and chronic degenerative and autoimmune diseases, including:
• Back pain
• Cartilage damage
• Chronic joint pain
• Chronic non-healing wounds
• Degenerative joints
• General inflammation
• Joint dysfunction
• Knee injuries
• Ligament tears
• Meniscus damage
• Muscle tears
• Nerve Injury
• Repetitive motion injuries
• Soft tissue injuries
• Tendon tears
• Aesthetics application
In some cases, patients who undergo exosome treatment for pain, inflammation, degenerative diseases, or strains experience significant improvement following a single treatment. On average, however, the full effects and relief of exosome treatment will occur within four to six weeks from the initial injection.
Of course, your suitability for exosome therapy will be determined by your health care provider based on a thorough examination, your medical history, and your individual needs before an appropriate treatment plan is designed.
That’s where the multiple growth factor proteins in exosomes can help. Only 30-150mm in size, exosomes are much smaller particles than stem cells – about 1/100th – and have better permeability, which means they can get into and out of tissues much more efficiently. They are even able to pass the blood brain barrier (which not many things can do) and get into the brainstem to help with more advanced neurologic conditions.
They can help modulate the inflammatory regenerative process by activating and recruiting your own helper and stem cells to the affected area, triggering revascularization (the creation of new blood vessels) in the area and reducing the inflammatory response to enable natural healing.
At RenewU Medical, we offer the highest quality, purified exosomes for therapeutic use, along with other regenerative medical options such as stem cell and PRP therapy. Please contact us at (561) 331-2983 to learn more about our family of regenerative medicine products and services, and to schedule a private consultation. And while you’re at it, ask about our special Introductory Offer!